MAPK signaling
| PAG Title | MAPK signaling |
| PAG ID | WIG001836 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | The transmission of extracellular signals into their intracellular targets is mediated by a network of interacting proteins. MAPK cascades are triple kinase pathways that include a MKKK (MAPK kinase kinase), a MKK (MAPK kinase) and a terminal MAPK. The major MAPK cascades are the Raf–MKK–ERK (ERK= extracellular signal regulated kinase).Rac-MKK-JNK JNK= c-Jun N-terminal kinase), and Rac-MKK-p38 MAPK. Fully activated ERK, JNK and p38 MAPK has a variety of substrates at the plasma membrane, in the cytosol and in the nucleus that regulate important aspects of cell physiology. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,950 |
| Information Content | Rich |
| Other IDs | SPIKE00018 |
| Base PAG ID | WIG001836 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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